This is the protocol for a review and there is no abstract. The objectives are as follows:
In preterm or low birth weight infants following hospital discharge, does feeding with calorie and protein-enriched formula milk compared with standard term formula milk improve growth and development?
In separate comparisons, we will compare calorie and protein-enriched formula milk versus standard term formula milk in babies fed formula milk exclusively, in human breast milk-fed babies fed formula as supplement, and in babies where the calorie and protein-enriched formula is used either as sole diet or as a supplement to breast milk.
If the data are available, we will undertake sub-group analyses of:
1. infants of very low birth weight (less than 1.5 kilograms) or who are very preterm at birth (less than 32 weeks)
2. infants who remain small for gestational age (less than 10th percentile for weight) at hospital discharge
3. infants with chronic lung disease requiring home supplemental oxygen therapy
4. infants fed standard term formula versus infants fed "preterm" formula (energy content between greater than 75 Kcal/100ml and protein content at least 2.0 grams/100ml)
5. infants fed standard term formula versus infants fed "post-discharge" formula (energy content between 72 and 75 Kcal/100ml and protein content at least 1.6 grams/100ml, but less than 2.0 grams/100ml)