Synthesis of N,N′-Disulfonylamidines from Sulfonamides and Alkynes by a Two-Step, One-Pot Reaction with Nonafluorobutanesulfonyl Azide

Authors

  • José Ramón Suárez,

    Corresponding author
    1. Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
    • Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
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  • Joanna Kwiczak,

    1. Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
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  • Katarzyna Grenda,

    1. Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
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  • M. Luisa Jimeno,

    1. Centro de Química Orgánica “Lora Tamayo”, CENQUIOR-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain
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  • Jose Luis Chiara

    Corresponding author
    1. Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
    • Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain, Fax: (+34)-915644853
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Abstract

Nonafluorobutanesulfonyl azide is an advantageous alternative to triflyl azide for the efficient synthesis of sulfonyl azides from sulfonamides in terms of its higher reactivity, lower cost, and non-hazardous nature. The reagent has proven its utility in a novel synthesis of N,N′-disulfonylamidines from available sulfonamides by a copper-catalyzed two-step, one-pot sequential process with added terminal alkynes.

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