Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms

Authors

  • S. C. Jacobson McEwen,

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
    2. Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA, USA
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  • C. G. Connolly,

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
    2. Department of Psychiatry, University of California, San Francisco, CA, USA
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  • A. M. C. Kelly,

    1. Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY, USA
    2. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
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  • I. Kelleher,

    1. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
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  • E. O'Hanlon,

    1. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
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  • M. Clarke,

    1. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
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  • M. Blanchard,

    1. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
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  • S. McNamara,

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
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  • D. Connor,

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
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  • E. Sheehan,

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
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  • G. Donohoe,

    1. Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
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  • M. Cannon,

    Corresponding author
    1. Department of Psychiatry and Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
    2. Department of Psychiatry, Beaumont Hospital, Dublin, Ireland
    • Sarah Jacobson McEwen, UCLA Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Office 27-362, 760 Westwood Plaza, Los Angeles, CA 90095, USA.E-mail: smcewen@mednet.ucla.edu

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    • Both authors contributed equally to this work.

  • H. Garavan

    1. School of Psychology, Trinity College Dublin, Dublin, Ireland
    2. Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
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    • Both authors contributed equally to this work.


Abstract

Objective

Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who reported psychotic symptoms (the extended psychosis phenotype).

Method

This study investigated intrinsic functional connectivity (iFC) during resting-state functional magnetic resonance imaging (fMRI; rs-fMRI). Following screening in schools, 11 non-treatment seeking, youth with psychotic symptoms (aged 11–13) and 14 community controls participated in the study. Seed regions of interest comprised brain regions previously shown to exhibit aberrant activation during inhibitory control in adolescents with psychotic symptoms.

Results

Relative to controls, adolescents with psychotic symptoms exhibited reduced iFC between regions supporting inhibitory control. Specifically, they showed weaker iFC between the right inferior frontal gyrus (IFG) and the cingulate, IFG and the striatum, anterior cingulate and claustrum, and precuneus and supramarginal gyrus. Conversely, the psychotic symptoms group exhibited stronger iFC between the superior frontal gyrus and claustrum and IFG and lingual gyrus.

Conclusion

The present findings are the first to reveal aberrant functional connectivity in resting-state networks in a community sample of adolescents with psychotic symptoms and suggest that disruption in integration between distributed neural networks (particularly between prefrontal, cingulate and striatal brain regions) may be a key neurobiological feature of the extended psychosis phenotype.

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